IEEE Transactions on Biomedical Engineering

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Soft Nanomembrane Sensors and Flexible Hybrid Bioelectronics for Wireless Quantification of Blepharospasm
This article introduces a soft nanomembrane bioelectronic system that offers wireless, quantitative detection of blepharospasm (BL). A set of computational and experimental studies of materials and mechanics provides the fundamental design factors for the soft bioelectronics. The nanomembrane electrodes, mounted around the eyes, are capable of measuring clinical symptoms, including the frequency of blinking, the duration of eye closures, and combinations of blinking and spasms. The deep-learning algorithm offers objective, real-time classification of critical pathological features in BL. The wearable electronic system outperforms the conventional manual clinical rating, proven by a pilot study with 13 patients... Read more
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Epilepsy-on-a-chip System for Antiepileptic Drug Discovery
    Development of antiepileptic drugs is currently complicated by the long time course of epileptogenesis. This process occurs on a time scale of weeks to months in animal models, and takes up to two weeks in an in vitro organotypic hippocampal... Read more
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In-Vivo Electrophysiological Study of Induced Ventricular Tachycardia in Intact Rat Model of Chronic Ischemic Heart Failure
Ventricular tachycardia and ventricular fibrillation are the most common causes of sudden cardiac death in patients with chronic heart failure (CHF). Furthermore, as the next generation of therapeutics for heart failure is developed, it is increasingly important to have reliable... Read more
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Orientation Independent Catheter-Based Characterization of Myocardial Activation
Cardiac electrogram (EGM) signals and electrophysiologic (EP) characteristics derived from them such as amplitude and timing are central to the diagnosis and therapeutic management of arrhythmias. Bipolar EGMs are often used but possess polarity and shape dependence on catheter orientation... Read more
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High-Resolution Electrogastrogram: A Novel, Noninvasive Method for Determining Gastric Slow-Wave Direction and Speed
Although the importance of gastrointestinal (GI) health is increasingly recognized, the lack of a robust, non-invasive system for objective GI electrophysiologic assessment hinders complete understanding of the impact of GI in health and disease.  Novel approaches to diagnose and understand... Read more
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Optimizing the Electrical Stimulation of Retinal Ganglion Cells
Abstract Epiretinal prostheses aim to restore visual perception in the blind through electrical stimulation of surviving retinal ganglion cells (RGCs). While the effects of several waveform parameters (e.g., phase duration) on stimulation efficacy have been described, their relative influence remains unclear.... Read more
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Enhancement of Bilateral Cortical Somatosensory Evoked Potentials to Intact Forelimb Stimulation Following Thoracic Contusion Spinal Cord Injury in Rats
Abstract The adult central nervous system is capable of significant reorganization and adaptation following neurotrauma. After a thoracic contusive spinal cord injury (SCI) neuropathways that innervate the cord below the epicenter of injury are damaged, with minimal prospects for functional recovery. In contrast, pathways above the... Read more
TBME 60th Anniversary
The Past, Present, and Future of Real-Time Control in Cellular Electrophysiology
Jennifer A. Bauer, Katherine M. Lambert, and John A. White, Brain Institute, University of Utah Volume 61, Issue 5, Page:1448-1456 Control-based strategies have been critical for advancing our understanding of the mechanisms of electrical excitability in nerve and muscle cells.  For example, in... Read more
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Minimizing Cytosol Dilution in Whole-Cell Patch-Clamp Experiments
Samsoon Inayat, Lawrence H. Pinto, and John B. Troy Volume: 60, Issue: 7, Page(s): 2042-2051 The cell is the basic unit of life. While living, it responds to diverse internal and external stimuli and exchanges materials across its plasma membrane through various... Read more