IEEE Transactions on Biomedical Engineering

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A Novel Capsule-Delivered Enteric Drug-Injection Device for Delivery of Systemic Biologics: A Pilot Study in a Porcine Model
Here, we report a swallowable capsule for intestinal drug delivery (SCIDD) with the potential of directly injecting biological therapeutics into the small intestine wall. The design, optimization, and validation of the SCIDD's primary subsystems were performed both ex-vivo and in-vivo. The assembled capsule was further tested in vivo to validate the actuation sequence which showed a 70% success rate in an animal model. A drug delivery study indicated systemic uptake of adalimumab via SCIDD compared with luminal delivery in the small intestine. The pilot study presented here establishes that the novel platform could be used to orally deliver systemic biologics... Read more
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A factorial approach for optimizing the design parameters of a tissue attachment mechanism for drug delivery
In this work, a tissue attachment mechanism (TAM) was designed, optimized, and validated for a drug delivery ingestible capsule robot with a straightforward and mass-producible fabrication process. For the first time with this type of device, an optimization process was conducted on live tissue incorporating the dynamic nature of tissue response, and an attachment success rate of 92% was achieved. The duration test in a live and mobile large animal model showed a consistent and reliable attachment duration of over 30 hours, making the TAM a suitable candidate for a 24-hour long systemic drug delivery platform... Read more
Untargeted Large Volume Hyperthermia Reduces Tumor Drug Uptake From Thermosensitive Liposomes
Goal: The impact of hyperthermia (HT) method on tumor drug uptake with thermosensitive liposomes (TSL) is not well understood. Methods: We created realistic three-dimensional (3-D) computer models that simulate TSL-encapsulated doxorubicin (TSL-DOX) delivery in mouse tumors with three HT methods... Read more
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Electric Stimulus-Responsive Chitosan/MNP composite Microbeads for a Drug Delivery System
Direct drug administration has several shortcomings, for eg, poor target localization and specificity, opsonization, undesired systemic exposure, etc. Stimuli controlled Drug Delivery Substrates (DDS) not only sterically shield the drug from premature renal flushing, but also introduce the possibility of... Read more
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Use of Model Predictive Control and Artificial Neural Networks to Optimize the Ultrasonic Release of a Model Drug From Liposomes
The use of echogenic liposomes to deliver chemotherapeutic agents for cancer treatment has gained wide recognition in the last 20 years. Cancerous cells can develop multiple drug resistance (MDR), in part, due to the drop in concentration of chemotherapeutic agents... Read more
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Molecular Communication Model for Targeted Drug Delivery in Multiple Disease Sites With Diversely Expressed Enzymes
Targeted drug delivery (TDD) for disease therapy using liposomes as nanocarriers has received extensive attention in the literature. The liposome’s ability to incorporate capabilities such as long circulation, stimuli responsiveness, and targeting characteristics, makes it a versatile nanocarrier. Timely drug... Read more
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A Molecular Communications Model for Drug Delivery
This paper considers the scenario of a targeted drug delivery system, which consists of deploying a number of biological nanomachines close to a biological target (e.g., a tumor), able to deliver drug molecules in the diseased area. Suitably located transmitters... Read more