IEEE Journal of Translational Engineering in Health and Medicine

Articles, Published Articles
Intraoperative Localization of STN during DBS Surgery using a Data-driven Model
A new approach is presented for localizing the Subthalamic Nucleus (STN) during Deep Brain Stimulation (DBS) surgery based on microelectrode recordings (MERs). DBS is an accepted treatment for individuals living with Parkinson’s Disease (PD). This surgery involves implantation of a... Read more
Articles, Published Articles
A Miniature Dual-biomarker-based Sensing and Conditioning Device for Closed-loop DBS
  In this paper, a dual-biomarker-based neural sensing and conditioning device is proposed for closing the feedback loop in deep brain stimulation devices. The device explores both local field potentials (LFPs) and action potentials (APs) as measured biomarkers. It includes two... Read more
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Uncertainty Quantification of Oscillation Suppression during DBS in a Coupled Finite Element and Network Model
    Models of the cortico-basal ganglia network and volume conductor models of the brain can provide insight into the mechanisms of action of deep brain stimulation (DBS). In this study, the coupling of a network model, under parkinsonian conditions, to the... Read more
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Improvement of Pyramidal Tract Side Effect Prediction Using a Data-Driven Method in Subthalamic Stimulation
Subthalamic nucleus deep brain stimulation (STN DBS) is limited by the occurrence of pyramidal tract side effect (PTSE) induced by electrical activation of the pyramidal tract. Predictive models are needed to assist the surgeon during the electrode trajectory pre-planning. The... Read more
Featured Articles, Special Issue: BRAIN
A Novel Lead Design for Modulation and Sensing of Deep Brain Structures
Allison T. Connolly,Rio J. Vetter, Jamille F. Hetke, Benjamin A. Teplitzky, Daryl R. Kipke, David S. Pellinen, David J. Anderson, Kenneth B. Baker, Jerrold L. Vitek, and Matthew D. Johnson, University of Minnesota, NeuroNexus, USA. This work aims to develop and characterize... Read more
Articles, Published Articles
neuroBi: A Highly Configurable Neurostimulator for a Retinal Prosthesis and Other Applications
This paper presents an innovative neurostimulator for use with a suprachoroidal retinal prosthesis. Clinical test results are described which show it to be effective in eliciting visual percepts in a profoundly vision-impaired subject with approximately 20 years of light perception... Read more
Articles, Published Articles
Development of a Compact Rectenna for Wireless Powering of a Head-mountable Deep Brain Stimulation Device
Design of a rectangular spiral planar inverted-F antenna (PIFA) at 915 MHz for wireless power transmission applications is proposed. The antenna and the rectifying circuitry form a rectenna which can produce DC power from a distant radio frequency energy transmitter.... Read more
Articles, Published Articles
A Low Power Micro Deep Brain Stimulation Device for Murine Preclinical Research
Deep brain stimulation has emerged as an effective medical procedure that has therapeutic efficacy in a number of neuropsychiatric disorders. Preclinical research involving laboratory animals is being conducted to study the principles, mechanisms, and therapeutic effects of deep brain stimulation.... Read more
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Influence of Uncertainties in the Material Properties of Brain Tissue on the Probabilistic Volume of Tissue
Christian Schmidt, Peadar Grant,  Madeleine Lowery,  Ursula Van Rienen Volume: 60, Issue: 5, Page: 1378 – 1387 Deep brain stimulation (DBS) has evolved as a widely employed procedure to treat the symptoms of motor skill disorders such as Parkinson’s disease, essential tremor and dystonia. Although successfully employed across... Read more
Featured Articles
Neuromodulation for Brain Disorders: Challenges and Opportunities
Matthew D. Johnson, Hubert H. Lim, Theoden I. Netoff, Allison T. Connolly, Nessa Johnson, Abhrajeet Roy, Abbey Holt, Kelvin O. Lim, James R. Carey, Jerrold L. Vitek, Bin He Volume: 60, March Special Issue, Publication Year: 2013 (Full Article) The field of neuromodulation... Read more