IEEE Transactions on Biomedical Engineering

This work aims to improve on the patient comfort and reduce the reliance on intraoperative magnetic resonance image (MRI) guidance for transcranial focused ultrasound therapy. We present a technique for the automated design of a scaffold to house re-usable ultrasound transducers. The scaffold can be optimised for patient-specific brain targets and to conform to the patient’s head. We demonstrated the feasibility of our system by way of numerical simulations and in-vivo testing in rodents. Our results demonstrated that the device could achieve focus through the human skull and safely open the blood-brain-barrier. Skull-conformal phased arrays stand to improve patient comfort and have the potential to accelerate the adoption of transcranial FUS therapy by improving access to the technology... Read more

         There has been increased effort to understand the neurophysiological effects of concussion aimed to move diagnosis and identification beyond current subjective behavioral assessments that suffer from poor sensitivity. Recent evidence suggests that event-related potentials (ERPs) measured with electroencephalography (EEG) are... Read more

   Braided multi-electrode probes (BMEPs) for neural interfaces comprise ultrafine microwire bundles interwoven into tubular braids. BMEPs provide highly flexible probes and tethers, and an open lattice structure with up to 24 recording/stimulating channels in precise geometries, currently all within a... Read more

   Data-driven spatial filtering algorithms optimize scores, such as the contrast between two conditions to extract oscillatory brain signal components. Most machine learning approaches for the filter estimation, however, disregard within-trial temporal dynamics and are extremely sensitive to changes in training... Read more

       Qualitative assessments of the blink reflex are used clinically to assess neurological status in critical care, operating room, and rehabilitative settings. Despite decades of literature supporting the use of quantitative measurements of the blink reflex in the evaluation of multiple... Read more

Abstract Magnetic stimulation delivered via 0.5-mm diameter coils was recently shown to activate retinal neurons; the small coil size raises the possibility that micromagnetic stimulation (μMS) could underlie a new generation of implanted neural prosthetics. Such an approach has several inherent... Read more

Nature article on the technological challenges involved in our billion-dollar research initiatives on understanding the workings of the brain. Read more at Nature.... Read more