IEEE Transactions on Biomedical Engineering
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Technical Validation of Multi-Section Robotic Bronchoscope with First Person View Control for Transbronchial Biopsies of Peripheral Lung
This study aims to validate the advantage of new engineering method to maneuver multi-section robotic bronchoscope with first person view control in transbronchial biopsy. Six physician operators with different skill levels in manual bronchoscopy were recruited and tasked to operate a manual and a robotic bronchoscope with a gamepad to the peripheral area placed in patient-derived lung phantoms. The use of the robotic bronchoscope via a gamepad showed statistically less physical demands and the ability to reach the 5th generation of the airway regardless of the experience in manual bronchoscopy... Read more
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Non-invasive treatment for coronary in-stent restenosis via wireless revascularization with nitinol active stent
We present a novel shape memory alloy nitinol type active stent for non-invasive restenosis treatment, which operates using a radiofrequency electro-thermo-mechanical actuation technique for wireless revascularization. The stent is equipped with sensing capability for in-artery blood pressure measurement and can provide multiple expansion to restore the blood flow. The electrical and mechanical properties, thermal and temporal response of the stent are characterized. In addition, ex vivo characterization of the developed stent is also performed. The achievable wireless revascularization capability eradicates the necessity of reintervention and repeat stenting procedure, whereas real-time wireless monitoring provides rapid indication of in-artery re-narrowing occurrence... Read more
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An Ellipsoidal Focused Ultrasound Transducer for Extend-Focus Photoacoustic Microscopy
This study propose an ellipsoidal focused ultrasound transducer (EUT) to solve the problem of sharp attenuation of transducer sensitivity and lateral resolution when transducer away from the focus position. Traditional high numerical aperture spherical focused ultrasound transducers (SUT) are widely used in photoacoustic microscopy (PAM) to provide high resolution, but their imaging field of view is limited. We verified the improvement of sound field distribution through simulation and hydrophone experiments. The improvement of the PAM system is proved by the phantom and in vivo experiment, which has great potential for promoting in vivo rapid-noninvasive PAM to clinical development... Read more
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The Contribution of Glycosaminoglycans/Proteoglycans to Aortic Mechanics in Health and Disease: A Critical Review
This review summarizes the current understanding of the mechanobiological functions of glycosaminoglycans (GAGs) and proteoglycans (PGs) in the normal aortic wall, as well as their potential impact on aortic diseases such as aneurysms and dissections. We identify knowledge gaps and propose paths of inquiry in hopes of ultimately enhancing the accuracy of mathematical models of aortic mechanics, and furthering clinical guidelines and standard of care. Specifically, we describe the swelling of GAGs/PGs and discuss their potential contributions to residual stresses and aortic stiffness. We also underscore different potential roles they may play in thoracic aortic aneurysm and abdominal aortic aneurysm... Read more
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Direct electrical stimulation of the human brain has inverse effects on the theta and gamma neural activities
Lech et. al studied the electrophysiological response to direct electrical stimulation (DES) systematically applied in human patients at a wide range of parameters, with particular focus on the neural activities associated with memory and cognition. Subjects were stimulated in blocks of alternating frequency and amplitude parameters during quiet wakefulness. Amplification of the theta (4–7 Hz) and attenuation of the gamma (29–52 Hz) power-in-band was observed with increasing the stimulation parameters. These findings reveal the utility of simple power-in-band features for understanding and optimizing the effects of electrical stimulation on brain activities and functions... Read more