IEEE Open Journal of Engineering in Medicine and Biology
Articles
Articles
RADxSM Tech: A New Paradigm for MedTech Development Overview of This Special Section
The papers in this special section focuses on the major interrelated components of Rapid Acceleration of Diagnostics (RADxSM) Tech, a National Institutes of Health (NIH)-funded program launched on April 29, 2020 to accelerate development, validation, and commercialization of innovative point-of-care...
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Posted on 10 OCT 2021
Articles
Untargeted Large Volume Hyperthermia Reduces Tumor Drug Uptake From Thermosensitive Liposomes
Krishna K. Ramajayam, A. Marissa Wolfe, Anjan Motamarry, Georges J. Nahhas, John Yost, Michael J. Yost, Dieter Haemmerich
Goal: The impact of hyperthermia (HT) method on tumor drug uptake with thermosensitive liposomes (TSL) is not well understood. Methods: We created realistic three-dimensional (3-D) computer models that simulate TSL-encapsulated doxorubicin (TSL-DOX) delivery in mouse tumors with three HT methods...
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Posted on 28 SEP 2021
Articles
A Novel Approach to Generate a Virtual Population of Human Coronary Arteries for In Silico Clinical Trials of Stent Design
Dimitrios S. Pleouras, Antonis I. Sakellarios, George Rigas, Georgia Karanasiou, Panagiota Tsompou, Gianna Karanasiou, Vassiliki Kigka, Savvas Kyriakidis, Vasileios C. Pezoulas, George Gois, Nikolaos Tachos, Aidonis Ramos, Gualtiero Pelosi, Silvia Rocchiccioli, Lampros K. Michalis, Dimitrios I. Fotiadis
Goal: To develop a cardiovascular virtual population using statistical modeling and computational biomechanics. Methods: A clinical data augmentation algorithm is implemented to efficiently generate virtual clinical data using a real clinical dataset. An atherosclerotic plaque growth model is employed to...
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Posted on 28 SEP 2021
Articles
Non-Invasive Cardiac and Respiratory Activity Assessment From Various Human Body Locations Using Bioimpedance
Objective: Bioimpedance sensing is a powerful technique that measures the tissue impedance and captures important physiological parameters including blood flow, lung movements, muscle contractions, body fluid shifts, and other cardiovascular parameters. This paper presents a comprehensive analysis of the modality...
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Posted on 28 SEP 2021
Articles
Machine Learning Approach for Biopsy-Based Identification of Eosinophilic Esophagitis Reveals Importance of Global features
Tomer Czyzewski, Nati Daniel, Mark Rochman, Julie M. Caldwell, Garrett A. Osswald, Margaret H. Collins, Marc E. Rothenberg, Yonatan Savir
Eosinophilic esophagitis (EoE) is an allergic inflammatory condition characterized by eosinophil accumulation in the esophageal mucosa. EoE diagnosis includes a manual assessment of eosinophil levels in mucosal biopsies–a time-consuming, laborious task that is difficult to standardize. One of the main...
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Posted on 28 SEP 2021
Articles
Comprehensive Assessment of Fine-Grained Wound Images Using a Patch-Based CNN With Context-Preserving Attention
Chronic wounds affect 6.5 million Americans. Wound assessment via algorithmic analysis of smartphone images has emerged as a viable option for remote assessment. Methods: We comprehensively score wounds based on the clinically-validated Photographic Wound Assessment Tool (PWAT), which comprehensively assesses...
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Posted on 28 SEP 2021
Articles
Reducing COVID-19 Cases and Deaths by Applying Blockchain in Vaccination Rollout Management
Because a fast vaccination rollout against coronavirus disease 2019 (COVID-19) is critical to restore daily life and avoid virus mutations, it is tempting to have a relaxed vaccination-administration management system. However, a rigorous management system can support the enforcement of...
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Posted on 28 SEP 2021
Articles
Integrating County-Level Socioeconomic Data for COVID-19 Forecasting in the United States
The United States (US) is currently one of the countries hardest-hit by the novel SARS-CoV-19 virus. One key difficulty in managing the outbreak at the national level is that due to the US’ diversity, geographic spread, and economic inequality, the...
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Posted on 28 SEP 2021
Articles
A Framework for Efficient N-Way Interaction Testing in Case/Control Studies With Categorical Data
Aristos Aristodimou, Athos Antoniades, Efthimios Dardiotis, Eleni M. Loizidou, George M. Spyrou, Christina Votsi, Kyproula Christodoulou, Marios Pantzaris, Nikolaos Grigoriadis, Georgios M. Hadjigeorgiou, Theodoros Kyriakides, Constantinos S. Pattichis
Most common diseases are influenced by multiple gene interactions and interactions with the environment. Performing an exhaustive search to identify such interactions is computationally expensive and needs to address the multiple testing problem. A four-step framework is proposed for the...
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Posted on 28 SEP 2021
Articles
Stand-Up, Squat, Lunge, and Walk With a Robotic Knee and Ankle Prosthesis Under Shared Neural Control
Emerging robotic knee and ankle prostheses present an opportunity to restore the biomechanical function of missing biological legs, which is not possible with conventional passive prostheses. However, challenges in coordinating the robotic prosthesis movements with the user’s neuromuscular system and...
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Posted on 28 SEP 2021