IEEE Journal of Translational Engineering in Health and Medicine's unique aim is to publish original work in the intersection of engineering and clinical translation. The journal's focus is interdisciplinary collaborations between researchers, healthcare providers, and industry and aims to publish results and best practices from these translational efforts.
Mayo Systems Electrophysiology Laboratory, Department of Neurology, Mayo Clinic, Rochester, MN, USA and Czech Institute of Informatics, Robotics and Cybernetics, Czech Technical University in Prague, Czech Republic and Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.
JTEHM, Articles, Published ArticlesIntegrating Brain Implants with Local and Distributed Computing Devices: A Next Generation Epilepsy Management System
Vaclav Kremen, Benjamin H. Brinkmann, Inyong Kim, Hari Guragain, Mona Nasseri, Abigail L. Magee, Tal Pal Attia, Peter Nejedly, Vladimir Sladky, Nathanial Nelson, SuYoune Chang, Jeffrey A. Herron, Tom Adamski, Steven Baldassano, Jan Cimbalnik, Vince Vasoli, Elizabeth Fehrmann, Tom Chouinard, Edward E. Patterson, Brian Litt, Matt Stead, Jamie Van Gompel, Beverly K. Sturges, Chelsea M. Crowe, Timothy Denison, Gregory A. Worrell
Brain stimulation has emerged as an effective treatment for a wide range of neurological and psychiatric diseases. Parkinson’s disease, epilepsy, and essential tremor have FDA indications for electrical brain stimulation using intracranially implanted electrodes. Interfacing implantable brain devices with local... Read more
Posted on 19 SEP 2018
TBME, Featured ArticlesDirect electrical stimulation of the human brain has inverse effects on the theta and gamma neural activities
Michał Lech, Brent M. Berry, Cagdas Topcu, Vaclav Kremen, Petr Nejedly, Bradley Lega, Robert E. Gross, Michael R. Sperling, Barbara C. Jobst, Sameer A. Sheth, Kareem A. Zaghloul, Kathryn A. Davis, Gregory A. Worrell, Michal T. Kucewicz
Lech et. al studied the electrophysiological response to direct electrical stimulation (DES) systematically applied in human patients at a wide range of parameters, with particular focus on the neural activities associated with memory and cognition. Subjects were stimulated in blocks of alternating frequency and amplitude parameters during quiet wakefulness. Amplification of the theta (4–7 Hz) and attenuation of the gamma (29–52 Hz) power-in-band was observed with increasing the stimulation parameters. These findings reveal the utility of simple power-in-band features for understanding and optimizing the effects of electrical stimulation on brain activities and functions... Read more
Posted on 30 NOV 2021