Vaclav Kremen

Mayo Systems Electrophysiology Laboratory, Department of Neurology, Mayo Clinic, Rochester, MN, USA and Czech Institute of Informatics, Robotics and Cybernetics, Czech Technical University in Prague, Czech Republic and Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.

Associated articles

JTEHM, Articles, Published Articles
Integrating Brain Implants with Local and Distributed Computing Devices: A Next Generation Epilepsy Management System
                          Brain stimulation has emerged as an effective treatment for a wide range of neurological and psychiatric diseases. Parkinson’s disease, epilepsy, and essential tremor have FDA indications for electrical brain stimulation using intracranially implanted electrodes. Interfacing implantable brain devices with local... Read more
TBME, Featured Articles
Direct electrical stimulation of the human brain has inverse effects on the theta and gamma neural activities
Lech et. al studied the electrophysiological response to direct electrical stimulation (DES) systematically applied in human patients at a wide range of parameters, with particular focus on the neural activities associated with memory and cognition. Subjects were stimulated in blocks of alternating frequency and amplitude parameters during quiet wakefulness. Amplification of the theta (4–7 Hz) and attenuation of the gamma (29–52 Hz) power-in-band was observed with increasing the stimulation parameters. These findings reveal the utility of simple power-in-band features for understanding and optimizing the effects of electrical stimulation on brain activities and functions... Read more